Transliteration and Meaning:
The Greek word γάγγραινα (gangraina), pronounced GAN-gray-nah, is a term that refers to a serious medical condition known today as gangrene, where body tissue dies due to loss of blood supply, typically from an infection or underlying health condition. The word is derived from the verb granô, which means “to gnaw” or “to eat away,” indicative of the destructive nature of the condition. In its primary meaning, gangraina conveys the sense of something that spreads destructively, similar to how gangrene spreads in the body.

Lexical Insights and Biblical Usage:
According to BDAG (Bauer, Danker, Arndt, and Gingrich), gangraina specifically refers to a “disease that spreads and causes destruction, gangrene.” Thayer’s Lexicon elaborates that gangraina is a medical term describing an ulcerous condition where flesh becomes mortified and decomposes. Strong’s Exhaustive Concordance also emphasizes the destructive nature of this condition, which figuratively can describe anything that spreads harmfully, like false teachings.

In the New Testament, the word gangraina appears only once in 2 Timothy 2:17, where Paul warns against the spread of false teachings, likening them to gangrene: “And their word will eat as doth a canker (gangraina).” This metaphor emphasizes the insidious and destructive nature of false doctrines, which, like gangrene, can spread rapidly and cause extensive damage if not addressed.

Classical Greek Usage:
In classical Greek literature, gangraina was used in a more medical context, often describing an actual physical condition. Three notable examples include:

1. Hippocrates (c. 460–370 BC) frequently used the term gangraina in his medical writings to describe the necrosis of tissues, emphasizing the need for early intervention to prevent the spread of the condition.
2. Galen (c. 129–c. 200 AD), another prominent Greek physician, used gangraina to refer to a condition where an inflamed area of the body becomes infected and starts to decay, often leading to amputation to prevent further spread.
3. Aretaeus of Cappadocia (c. 81–c. 138 AD), a Greek physician, also discussed gangraina in his works, warning of its rapid progression and the severe consequences if not treated promptly.

These examples show that gangraina was a well-known term in the medical community of the ancient world, used to describe a serious and often life-threatening condition.

Summary:
The Greek word γάγγραινα (gangraina) is a vivid term that originally described a severe medical condition involving the decay and death of body tissue. The word is rooted in the idea of something that “gnaws” or “eats away,” reflecting the destructive nature of gangrene. In the New Testament, gangraina is used metaphorically by Paul in 2 Timothy 2:17 to describe the damaging spread of false teachings, comparing it to the spread of gangrene. Classical Greek literature, particularly in medical writings by Hippocrates, Galen, and Aretaeus, used the term to discuss the physical condition of gangrene, emphasizing the severity and danger of the disease. Overall, gangraina is a powerful term that conveys both physical and metaphorical destruction, making it a significant word in both medical and theological contexts.